From Molecule to Magnet: A Literature Review of MultiHance (Gadobenate Dimeglumine) – 7th Edition – CE

Currently, 9 gadolinium-based contrast agents (GBCAs) are approved for clinical use in the United States, and they vary by molecular structure, ability to interact with serum proteins, relaxivity, concentration, and stability. These varying properties have clinical significance in terms of lesion enhancement capability and patient safety. To better understand the potential impact of these properties on efficacy and safety, healthcare professionals in the field of radiology require education that contributes to their ability to differentiate between the various GBCAs, and to select the optimal agent for different applications and patient populations. Education on the subject of magnetic resonance (MR) safety, including nephrogenic systemic fibrosis (NSF), acute adverse reactions to contrast media, and gadolinium retention, is critical, and until recently, was not part of the core curriculum in the training of healthcare professionals in the field of radiology. Much of the existing information is theoretical and does not provide practical information for the avoidance of adverse outcomes.